منابع مشابه
Reprogramming for cardiac regeneration
Treatment of cardiovascular diseases remains challenging considering the limited regeneration capacity of the heart muscle. Developments of reprogramming strategies to create in vitro and in vivo cardiomyocytes have been the focus point of a considerable amount of research in the past decades. The choice of cells to employ, the state-of-the-art methods for different reprogramming strategies, an...
متن کاملHIF1α and metabolic reprogramming in inflammation.
HIF1α is a common component of pathways involved in the control of cellular metabolism and has a role in regulating immune cell effector functions. Additionally, HIF1α is critical for the maturation of dendritic cells and for the activation of T cells. HIF1α is induced in LPS-activated macrophages, where it is critically involved in glycolysis and the induction of proinflammatory genes, notably...
متن کاملDirect Cardiac Reprogramming: Advances in Cardiac Regeneration
Heart disease is one of the lead causes of death worldwide. Many forms of heart disease, including myocardial infarction and pressure-loading cardiomyopathies, result in irreversible cardiomyocyte death. Activated fibroblasts respond to cardiac injury by forming scar tissue, but ultimately this response fails to restore cardiac function. Unfortunately, the human heart has little regenerative ab...
متن کاملCritical factors for cardiac reprogramming.
Cellular reprogramming achieved by somatic nuclear transfer or cell fusion has long been recognized.1 The potency of specific transcription factors as cell fate determinants was first demonstrated by the discovery of MyoD, a master regulator for skeletal muscle differentiation, and by the subsequent identification of several genes as lineageconverting transcription factors in blood cells.2,3 Th...
متن کاملNanotechnology-Based Cardiac Targeting and Direct Cardiac Reprogramming: The Betrothed
Cardiovascular diseases represent the first cause of morbidity in Western countries, and chronic heart failure features a significant health care burden in developed countries. Efforts in the attempt of finding new possible strategies for the treatment of CHF yielded several approaches based on the use of stem cells. The discovery of direct cardiac reprogramming has unveiled a new approach to h...
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ژورنال
عنوان ژورنال: Science
سال: 2017
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.358.6362.494-b